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Cholesterol Control with Niacin


All pages are informative – not therapeutic. Read first about VitaminB3.

Niacin (=nicotinic acid) is a form of vitamin B3. However, the best-selling form of vitamin B3 is niacinamide; but it does not lead to cholesterol control. Be careful that you get the right form.

Dr. Hoffer – Orthomolecular medicine for everyone 2008, pages 71 and 239-40 are reproduced in the next 2 sections:



The National Institutes of Health in Washington, D.C. recommends that elevated cholesterol levels be reduced by diet and when this is not sufficient when using substances such as niacin. Niacin has the following therapeutic uses:

It reduces LDL cholesterol. The higher the initial value, the greater the effect. It lowers triglycerides in the blood. It lowers lipoprotein (s) levels and raises HDL levels. It inhibits free fatty acid mobilization. It has anti-inflammatory properties that are now considered important in cardiovascular diseases. It restores the intestinal tract’s permeability to normal levels. [These are just some of niacin’s many positive effects]

Vitamin B3 plays a particularly important role in the prevention or treatment of senility. Dr. Hoffer has found vitamin B3 very effective in restoring memory, improving energy, reducing the need for sleep and raising awareness. Niacin is particularly valuable because of its pronounced beneficial effect on the blood vessel system (the vascular system): as mentioned, it lowers cholesterol, triglycerides, and low density lipoproteins and raises high density lipoproteins. This reduces the development of atherosclerosis and decreases mortality from vascular accidents. The optimum dose of niacin varies between 3,000 mg and 6,000 mg per day. day in three divided doses. Generally, it is best to start with smaller doses and slowly increase them.

Niacin can cause the tingling of the skin (flush) and redness as histamine is released and the capillaries expand. The effect is reduced by the use of slow release niacin, and also by frequent use, so that the histamine stores do not become large. Since niacin provides a more effective sleep, it is a good idea to ingest just before bedtime. The flush can be moderated by aspirin (one tablet before each dose of niacin) for a few days, antihistamines (eg, vitamin C) or sedatives. If niacin cannot be tolerated, “inositol niacinate” is another and slightly weaker version of vitamin B3 an option.

An acquaintance of me (AC) would try niacin instead of statin to avoid statin side effects. I showed her a print of Dr. Hoffers method. She asked her doctor if she would be in danger of dying if she tried the method for 3 months. The doctor replied that she was not, but that the method probably did not work. One morning I got a call from her. She said that after taking sustained release niacin, it had begun to creep strangely on the scalp and then into ears and cheeks. when she looked in the mirror, ears and cheeks were red. The slightly tingling sensation spread to other body parts. I immediately said it was the so-called flush, and not a sign that she was leaving this world, on the contrary. Three months later, she was given blood tests. During the subsequent consultation with the doctor, he seemed somewhat embarrassed when he said that the total cholesterol had decreased from 5.4 to 4.1 [ie far below the 5.0 mmol / l limit and that the related other numbers also dropped to normal values.

The National Board of Health FDA in the US,
mentions cholesterol control with bl. a. niacin and omega-3. Thus, omega-3 is a third natural (orthomolecular) option, eg in the form of Budwig’s omega-3 cream.

Sustained release

With sustained release or time release ie. slow release is generally required only half the dose. 

The dose as a starting point may be 500 mg per. 25 kg body weight per. day of sustained release niacin or Inositol Hexanicotinate, if the niacin cannot be tolerated.


It may be practical to purchase in USA to get mega sizes with sustained release.